In children with acute lymphocytic leukemia (ALL) or acute myeloid leukemia (AML), certain factors that can affect a child’s outlook (prognosis) are called prognostic factors. They help doctors decide how intense treatment needs to be. Prognostic factors seem to be more important in ALL than in Last Revised: February 12, 2019. Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): Analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern.
While the International Childhood Acute Lymphoblastic Leukaemia Workshop has recommended four categories for prognostic risk assessment in childhood ALL (Pui et al, 2001a), most adult ALL patients are classified into low or standard risk and high risk (Hoelzer et al, 1988). Finally, it must be borne in mind that any prognostic factor may be Cited by: 122. A predictive factor influences how a cancer will respond to a certain treatment. Prognostic and predictive factors are often discussed together and they both play a part in deciding on a treatment plan and a prognosis. Prognostic and predictive factors for ALL. The following are prognostic and predictive factors for .
Age and cytogenetics are the most important predictors of prognosis in adult ALL. Adults have a worse prognosis than children, with the worst outcome associated with patients older than 60 years.106 Cytogenetic abnormalities are the most important prognostic factor in adult ALL.1 Numeric chromosomal abnormalities (hyper- and hypodiploidy) are not as frequent in adults as in children and Author: Guillermo Garcia-Manero, Hagop M. Kantarjian, Charles A. Schiffer. Prognostic Indicator Guidance to aid identification of adult patients with advanced disease, in the last months/ year of life, who are in need of supportive and palliative care Version 2.25 July 06 Introduction and use of prognostic indicators.
T-cell lymphoblastic lymphoma (T-LBL) is a rare, aggressive neoplasm of precursor T cells that occurs mostly in adolescents and young adults. In this review, we describe the treatment of adult T-LBL with a focus on recent advances using pediatric-inspired acute lymphoblastic leukemia regimens, which have greatly improved outcome. We also discuss the development of prognostic indicators for T Cited by: 8. Prognostic factors in adult acute lymphoblastic leukaemia Jacob M. Rowe Rambam Health Care Campus and Technion, Israel Institute of Technology, Haifa, Israel Summary Treatment of acute lymphoblastic leukaemia (ALL) in adults presents a formidable challenge. While overall results have improved over the past 3 decades, the long-term survival forCited by: 122.